Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer’s and Parkinson’s diseases, has also been demonstrated. In this study, start...

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Bibliografiska uppgifter
I publikationen:J Enzyme Inhib Med Chem
Huvudupphovsmän: Poli, Giulio, Lapillo, Margherita, Granchi, Carlotta, Caciolla, Jessica, Mouawad, Nayla, Caligiuri, Isabella, Rizzolio, Flavio, Langer, Thierry, Minutolo, Filippo, Tuccinardi, Tiziano
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2018
Ämnen:
Short Communication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009924/
https://ncbi.nlm.nih.gov/pubmed/29747534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1469017
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