Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Monoacylglycerol lipase (MAGL) is an attractive therapeutic target for many pathologies, including neurodegenerative diseases, cancer as well as chronic pain and inflammatory pathologies. The identification of reversible MAGL inhibitors, devoid of the side effects associated to prolonged MAGL inacti...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Poli, Giulio, Lapillo, Margherita, Jha, Vibhu, Mouawad, Nayla, Caligiuri, Isabella, Macchia, Marco, Minutolo, Filippo, Rizzolio, Flavio, Tuccinardi, Tiziano, Granchi, Carlotta
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352951/
https://ncbi.nlm.nih.gov/pubmed/30696302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1571271
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