Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Monoacylglycerol lipase (MAGL) is an attractive therapeutic target for many pathologies, including neurodegenerative diseases, cancer as well as chronic pain and inflammatory pathologies. The identification of reversible MAGL inhibitors, devoid of the side effects associated to prolonged MAGL inacti...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Enzyme Inhib Med Chem
Main Authors: Poli, Giulio, Lapillo, Margherita, Jha, Vibhu, Mouawad, Nayla, Caligiuri, Isabella, Macchia, Marco, Minutolo, Filippo, Rizzolio, Flavio, Tuccinardi, Tiziano, Granchi, Carlotta
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Short Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352951/
https://ncbi.nlm.nih.gov/pubmed/30696302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1571271
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