Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

Monoacylglycerol lipase (MAGL) is an important enzyme of the endocannabinoid system that catalyzes the degradation of the major endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL is associated with pathological conditions such as pain, inflammation and neurodegenerative diseases like Parkinson’s an...

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Pubblicato in:Molecules
Autori principali: Jha, Vibhu, Biagi, Marzia, Spinelli, Valeria, Di Stefano, Miriana, Macchia, Marco, Minutolo, Filippo, Granchi, Carlotta, Poli, Giulio, Tuccinardi, Tiziano
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794939/
https://ncbi.nlm.nih.gov/pubmed/33375358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26010078
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