Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors

Inhibitors of human lactate dehydrogenase (hLDH5)—the enzyme responsible for the conversion of pyruvate to lactate coupled with oxidation of NADH to NAD(+)—are promising therapeutic agents against cancer because this enzyme is generally found to be overexpressed in most invasive cancer cells and is...

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Detalles Bibliográficos
Publicado en:Molecules
Main Authors: Poli, Giulio, Granchi, Carlotta, Aissaoui, Mohamed, Minutolo, Filippo, Tuccinardi, Tiziano
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2017
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149858/
https://ncbi.nlm.nih.gov/pubmed/29236080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22122217
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