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Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors

Inhibitors of human lactate dehydrogenase (hLDH5)—the enzyme responsible for the conversion of pyruvate to lactate coupled with oxidation of NADH to NAD(+)—are promising therapeutic agents against cancer because this enzyme is generally found to be overexpressed in most invasive cancer cells and is...

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Bibliografski detalji
Izdano u:Molecules
Glavni autori: Poli, Giulio, Granchi, Carlotta, Aissaoui, Mohamed, Minutolo, Filippo, Tuccinardi, Tiziano
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149858/
https://ncbi.nlm.nih.gov/pubmed/29236080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22122217
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