Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents

Inhibitors of human lactate dehydrogenase A (LDH-A) are promising therapeutic agents against cancer. The development of LDH-A inhibitors that possess cellular activities has so far proved to be particularly challenging, since the enzyme’s active site is narrow and highly polar. In the recent past, w...

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Detalhes bibliográficos
Publicado no:RSC Adv
Main Authors: Di Bussolo, Valeria, Calvaresi, Emilia C., Granchi, Carlotta, Del Bino, Linda, Frau, Ileana, Lang, Maria Chiara Dasso, Tuccinardi, Tiziano, Macchia, Marco, Martinelli, Adriano, Hergenrother, Paul J., Minutolo, Filippo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497792/
https://ncbi.nlm.nih.gov/pubmed/26167277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5RA00946D
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