The therapeutic potential of orphan GPCRs, GPR35 and GPR55

Por Shore, Derek M., Reggio, Patricia H.
Publicado no Front Pharmacol (2015)

Novel Insights into CB(1) Cannabinoid Receptor Signaling: A Key Interaction Identified between the Extracellular-3 Loop and Transmembrane Helix 2

Por Marcu, Jahan, Shore, Derek M., Kapur, Ankur, Trznadel, Megan, Makriyannis, Alexandros, Reggio, Patricia H., Abood, Mary E.
Publicado em 2013

(4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB(1) Receptor Inverse Agonist from the Class of Benzhydryl Piperazine...

Por Mahmoud, Mariam M., Olszewska, Teresa, Liu, Hui, Shore, Derek M., Hurst, Dow P., Reggio, Patricia H., Lu, Dai, Kendall, Debra A.
Publicado no Mol Pharmacol (2015)

Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor: BINDING SITE ELUCIDATION AND RELATIONSHIP TO G PROTEIN SIGNALING

Por Shore, Derek M., Baillie, Gemma L., Hurst, Dow H., Navas, Frank, Seltzman, Herbert H., Marcu, Jahan P., Abood, Mary E., Ross, Ruth A., Reggio, Patricia H.
Publicado em 2014

CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

Por Lucchesi, Valentina, Hurst, Dow P., Shore, Derek M., Bertini, Simone, Ehrmann, Brandie M., Allarà, Marco, Lawrence, Lyle, Ligresti, Alessia, Minutolo, Filippo, Saccomanni, Giuseppe, Sharir, Haleli, Macchia, Marco, Di Marzo, Vincenzo, Abood, Mary E., Reggio, Patricia H., Manera, Clementina
Publicado no J Med Chem (2014)

Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones

Por Meza-Aviña, Maria Elena, Lingerfelt, Mary A., Console-Bram, Linda M., Gamage, Thomas F., Sharir, Haleli, Gettys, Kristen E., Hurst, Dow P., Kotsikorou, Evangelia, Shore, Derek M., Caron, Marc G., Rao, Narasinga, Barak, Larry S., Abood, Mary E., Reggio, Patricia H., Croatt, Mitchell P.
Publicado no Bioorg Med Chem Lett (2016)

IDENTIFICATION OF THE GPR55 ANTAGONIST BINDING SITE USING A NOVEL SET OF HIGH POTENCY GPR55 SELECTIVE LIGANDS

Por Kotsikorou, Evangelia, Sharir, Haleli, Shore, Derek M., Hurst, Dow P., Lynch, Diane L., Madrigal, Karla E., Heynen-Genel, Susanne, Milan, Loribelle B., Chung, Thomas D.Y., Seltzman, Herbert H., Bai, Yushi, Caron, Marc G., Barak, Larry S., Croatt, Mitchell P., Abood, Mary E., Reggio, Patricia H.
Publicado em 2013

Pregnenolone Can Protect the Brain from Cannabis Intoxication

Por Vallée, Monique, Vitiello, Sergio, Bellocchio, Luigi, Hébert-Chatelain, Etienne, Monlezun, Stéphanie, Martin-Garcia, Elena, Kasanetz, Fernando, Baillie, Gemma L., Panin, Francesca, Cathala, Adeline, Roullot-Lacarrière, Valérie, Fabre, Sandy, Hurst, Dow P., Lynch, Diane L., Shore, Derek M., Deroche-Gamonet, Véronique, Spampinato, Umberto, Revest, Jean-Michel, Maldonado, Rafael, Reggio, Patricia H., Ross, Ruth A., Marsicano, Giovanni, Piazza, Pier Vincenzo
Publicado em 2014