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Novel Insights into CB(1) Cannabinoid Receptor Signaling: A Key Interaction Identified between the Extracellular-3 Loop and Transmembrane Helix 2
Activation of the cannabinoid CB(1) receptor (CB(1)) is modulated by aspartate residue D2.63(176) in transmembrane helix (TMH) 2. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB(1) receptor. Studies in class A G protein-coupled receptors have suggested an ionic interac...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3629795/ https://ncbi.nlm.nih.gov/pubmed/23426954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.201046 |
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