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Mapping the Structural Requirements in the CB(1) Cannabinoid Receptor Transmembrane Helix II for Signal Transduction

Amino acid residues in the transmembrane domains of the CB(1) receptor are important for ligand recognition and signal transduction. We used site-directed mutagenesis to identify the role of two novel and adjacent residues in the transmembrane helix II domain, Ile2.62 and Asp2.63. We investigated th...

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Detalhes bibliográficos
Main Authors: Kapur, Ankur, Samaniego, Patrick, Thakur, Ganesh A., Makriyannis, Alexandros, Abood, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767288/
https://ncbi.nlm.nih.gov/pubmed/18174385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.133256
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