Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and G(i) Protein-independent ERK1/2 Kinase Activation

Por Ahn, Kwang H., Mahmoud, Mariam M., Kendall, Debra A.
Publicado em 2012

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

Por Ahn, Kwang H., Mahmoud, Mariam M., Shim, Joong-Youn, Kendall, Debra A.
Publicado em 2013

Profiling Two Indole-2-Carboxamides for Allosteric Modulation of the CB1 Receptor

Por Ahn, Kwang H., Mahmoud, Mariam M., Samala, Sushma, Lu, Dai, Kendall, Debra A.
Publicado em 2013

The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase β

Por Huang, Ji, Alnajjar, Khadijeh S., Mahmoud, Mariam M., Eckenroth, Brian, Doublié, Sylvie, Sweasy, Joann B.
Publicado no J Biol Chem (2018)

Defective Nucleotide Release by DNA Polymerase Beta Mutator Variant E288K is the Basis of Its Low Fidelity

Por Mahmoud, Mariam M., Schechter, Allison, Alnajjar, Khadijeh S., Huang, Ji, Towle-Weicksel, Jamie, Eckenroth, Brian, Doublié, Sylvie, Sweasy, Joann B.
Publicado no Biochemistry (2017)

Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes

Por Fijen, Carel, Mahmoud, Mariam M., Kronenberg, Meike, Kaup, Rebecca, Fontana, Mattia, Towle-Weicksel, Jamie B., Sweasy, Joann B., Hohlbein, Johannes
Publicado no J Biol Chem (2020)

(4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB(1) Receptor Inverse Agonist from the Class of Benzhydryl Piperazine...

Por Mahmoud, Mariam M., Olszewska, Teresa, Liu, Hui, Shore, Derek M., Hurst, Dow P., Reggio, Patricia H., Lu, Dai, Kendall, Debra A.
Publicado no Mol Pharmacol (2015)

Structure-Activity Relationship Study of Indole-2-carboxamides Identifies a Potent Allosteric Modulator for the Cannabinoid Receptor 1 (CB1)

Por Mahmoud, Mariam M., Ali, Hamed I., Ahn, Kwang H., Damaraju, Aparna, Samala, Sushma, Pulipati, Venkata K., Kolluru, Srikanth, Kendall, Debra A., Lu, Dai
Publicado em 2013

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity

Por Liptak, Cary, Mahmoud, Mariam M, Eckenroth, Brian E, Moreno, Marcus V, East, Kyle, Alnajjar, Khadijeh S, Huang, Ji, Towle-Weicksel, Jamie B, Doublié, Sylvie, Loria, J Patrick, Sweasy, Joann B
Publicado no Nucleic Acids Res (2018)