Defective Nucleotide Release by DNA Polymerase Beta Mutator Variant E288K is the Basis of Its Low Fidelity

DNA polymerases synthesize new DNA during DNA replication and repair, and their ability to do so faithfully is essential to maintaining genomic integrity. DNA polymerase beta (Pol β) functions in Base Excision Repair (BER) to fill in single-nucleotide gaps, and variants of Pol β have been associated...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry
Main Authors: Mahmoud, Mariam M., Schechter, Allison, Alnajjar, Khadijeh S., Huang, Ji, Towle-Weicksel, Jamie, Eckenroth, Brian, Doublié, Sylvie, Sweasy, Joann B.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654646/
https://ncbi.nlm.nih.gov/pubmed/28945359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00869
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items