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The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase β

DNA polymerase β (Pol β) is essential for maintaining genomic integrity. During short-patch base excision repair (BER), Pol β incorporates a nucleotide into a single-gapped DNA substrate. Pol β may also function in long-patch BER, where the DNA substrate consists of larger gap sizes or 5′-modified d...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Huang, Ji, Alnajjar, Khadijeh S., Mahmoud, Mariam M., Eckenroth, Brian, Doublié, Sylvie, Sweasy, Joann B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166726/
https://ncbi.nlm.nih.gov/pubmed/30068550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004564
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