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The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase β
DNA polymerase β (Pol β) is essential for maintaining genomic integrity. During short-patch base excision repair (BER), Pol β incorporates a nucleotide into a single-gapped DNA substrate. Pol β may also function in long-patch BER, where the DNA substrate consists of larger gap sizes or 5′-modified d...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6166726/ https://ncbi.nlm.nih.gov/pubmed/30068550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004564 |
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