A pre-catalytic non-covalent step governs DNA polymerase β fidelity

DNA polymerase β (pol β) selects the correct deoxyribonucleoside triphosphate for incorporation into the DNA polymer. Mistakes made by pol β lead to mutations, some of which occur within specific sequence contexts to generate mutation hotspots. The adenomatous polyposis coli (APC) gene is mutated wi...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Alnajjar, Khadijeh S, Krylov, Ivan S, Negahbani, Amirsoheil, Haratipour, Pouya, Kashemirov, Boris A, Huang, Ji, Mahmoud, Mariam, McKenna, Charles E, Goodman, Myron F, Sweasy, Joann B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145665/
https://ncbi.nlm.nih.gov/pubmed/31732732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1076
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