DNA Polymerase Beta Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity Towards β-γ Bridging Group of the Incoming dNTP

The hydrophobic hinge region of DNA polymerase β (pol β) is located between the fingers and palm subdomains. The hydrophobicity of the hinge region is important for maintaining the geometry of the binding pocket and for selectivity of the enzyme. Various cancer-associated pol β variants in the hinge...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Alnajjar, Khadijeh S., Negahbani, Amirsoheil, Nakhjiri, Maryam, Krylov, Ivan, Kashemirov, Boris, McKenna, Charles, Goodman, Myron F., Sweasy, Joann B.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634933/
https://ncbi.nlm.nih.gov/pubmed/28862868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00713
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