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DNA Polymerase Beta Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity Towards β-γ Bridging Group of the Incoming dNTP
The hydrophobic hinge region of DNA polymerase β (pol β) is located between the fingers and palm subdomains. The hydrophobicity of the hinge region is important for maintaining the geometry of the binding pocket and for selectivity of the enzyme. Various cancer-associated pol β variants in the hinge...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5634933/ https://ncbi.nlm.nih.gov/pubmed/28862868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00713 |
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