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Probing DNA base-dependent leaving group kinetic effects on the DNA polymerase transition state
We examine the DNA polymerase β (pol β) transition state from a leaving group presteady-state kinetics perspective by measuring the rate of incorporation of dNTPs and corresponding novel β,γ-CXY-dNTP analogues, including individual β,γ-CHF and -CHCl diastereomers with defined stereochemistry at the...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6039227/ https://ncbi.nlm.nih.gov/pubmed/29889506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00417 |
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