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Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

[Image: see text] The first high-resolution crystal structure of spiroiminodihydantoin (dSp1) was obtained in the context of the DNA polymerase β active site and reveals two areas of significance. First, the structure verifies the recently determined S configuration at the spirocyclic carbon. Second...

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Библиографические подробности
Главные авторы: Eckenroth, Brian E., Fleming, Aaron M., Sweasy, Joann B., Burrows, Cynthia J., Doublié, Sylvie
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985455/
https://ncbi.nlm.nih.gov/pubmed/24649945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500270e
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