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Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin
The oxidation of guanine generates one of the most common DNA lesions, 8-oxo-7,8-dihydroguanine (8-oxoG). The further oxidation of 8-oxoG can produce either guanidinohydantoin (Gh) in duplex DNA or spiroiminodihydantoin (Sp) in nucleosides and ssDNA. Although Gh can be a strong block for replicative...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840191/ https://ncbi.nlm.nih.gov/pubmed/20166752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902195p |
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