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Kinetics of mismatch formation opposite lesions by the replicative DNA polymerase from bacteriophage RB69

The fidelity of DNA replication is under constant threat from the formation of lesions within the genome. Oxidation of DNA bases leads to the formation of altered DNA bases such as 8-oxo-7,8-dihydroguanine, commonly called 8-oxoG, and 2-hydroxyadenenine, or 2-OHA. In this work we have examined the i...

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Detalhes bibliográficos
Main Authors: Hogg, Matthew, Rudnicki, Jean, Midkiff, John, Reha-Krantz, Linda, Doublié, Sylvie, Wallace, Susan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849760/
https://ncbi.nlm.nih.gov/pubmed/20166748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901488d
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