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Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site

Abasic sites are common DNA lesions, which are strong blocks to replicative polymerases and are potentially mutagenic when bypassed. We report here the 2.8 Å structure of the bacteriophage RB69 replicative DNA polymerase attempting to process an abasic site analog. Four different complexes were capt...

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Detalhes bibliográficos
Main Authors: Hogg, Matthew, Wallace, Susan S, Doublié, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC391061/
https://ncbi.nlm.nih.gov/pubmed/15057283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600150
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