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A crystallographic study of the role of sequence context on thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex
Thymine glycol (Tg) is the most common oxidation product of thymine and is known to be a strong block for replicative DNA polymerases. A previously solved structure of the bacteriophage RB69 DNA polymerase (RB69 gp43) in complex with Tg in the sequence context 5’-G-Tg-G shed light on how Tg blocks p...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167065/ https://ncbi.nlm.nih.gov/pubmed/21781974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.07.007 |
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