A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol

Thymine glycol (Tg) is a common product of oxidation and ionizing radiation, including that used for cancer treatment. Although Tg is a poor mutagenic lesion, it has been shown to present a strong block to both repair and replicative DNA polymerases. The 2.65-Å crystal structure of a binary complex...

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Detalhes bibliográficos
Main Authors: Aller, Pierre, Rould, Mark A., Hogg, Matthew, Wallace, Susan S., Doublié, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783396/
https://ncbi.nlm.nih.gov/pubmed/17210917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606648104
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