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A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol
Thymine glycol (Tg) is a common product of oxidation and ionizing radiation, including that used for cancer treatment. Although Tg is a poor mutagenic lesion, it has been shown to present a strong block to both repair and replicative DNA polymerases. The 2.65-Å crystal structure of a binary complex...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783396/ https://ncbi.nlm.nih.gov/pubmed/17210917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606648104 |
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