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Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases κ and ζ in human cells
Thymine glycol (Tg) is the most common DNA lesion of thymine induced by interaction with reactive oxygen species. Because of the addition of hydroxyl groups at C5 and C6 in a Tg lesion, the damaged base loses its aromatic character and becomes nonplanar; consequently, the C5 methyl group protrudes i...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922520/ https://ncbi.nlm.nih.gov/pubmed/20660785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007795107 |
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