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Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases κ and ζ in human cells

Thymine glycol (Tg) is the most common DNA lesion of thymine induced by interaction with reactive oxygen species. Because of the addition of hydroxyl groups at C5 and C6 in a Tg lesion, the damaged base loses its aromatic character and becomes nonplanar; consequently, the C5 methyl group protrudes i...

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Détails bibliographiques
Auteurs principaux: Yoon, Jung-Hoon, Bhatia, Gita, Prakash, Satya, Prakash, Louise
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922520/
https://ncbi.nlm.nih.gov/pubmed/20660785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007795107
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