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Highly error-free role of DNA polymerase η in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells

Cyclobutane pyrimidine dimers (CPDs) constitute the most frequent UV-induced DNA photoproduct. However, it has remained unclear how human and other mammalian cells mitigate the mutagenic and carcinogenic potential of CPDs emanating from their replicative bypass. Here, we examine in human cells the r...

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書目詳細資料
Main Authors: Yoon, Jung-Hoon, Prakash, Louise, Prakash, Satya
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775276/
https://ncbi.nlm.nih.gov/pubmed/19822754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910121106
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