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Highly error-free role of DNA polymerase η in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells

Cyclobutane pyrimidine dimers (CPDs) constitute the most frequent UV-induced DNA photoproduct. However, it has remained unclear how human and other mammalian cells mitigate the mutagenic and carcinogenic potential of CPDs emanating from their replicative bypass. Here, we examine in human cells the r...

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書誌詳細
主要な著者: Yoon, Jung-Hoon, Prakash, Louise, Prakash, Satya
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775276/
https://ncbi.nlm.nih.gov/pubmed/19822754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910121106
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