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Requirement of DNA Polymerase η for Error-Free Bypass of UV-Induced CC and TC Photoproducts
The yeast RAD30-encoded DNA polymerase η (Polη) bypasses a cis-syn thymine-thymine dimer efficiently and accurately. Human DNA polymerase η functions similarly in the bypass of this lesion, and mutations in human Polη result in the cancer prone syndrome, the variant form of xeroderma pigmentosum. UV...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC88792/ https://ncbi.nlm.nih.gov/pubmed/11113193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.185-188.2001 |
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