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Replication past O(6)-Methylguanine by Yeast and Human DNA Polymerase η

O(6)-Methylguanine (m6G) is formed by the action of alkylating agents such as N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) on DNA. m6G is a highly mutagenic and carcinogenic lesion, and it presents a block to synthesis by DNA polymerases. Here, we provide genetic and biochemical evidence for the invo...

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Udgivet i:Mol Cell Biol
Principais autores: Haracska, Lajos, Prakash, Satya, Prakash, Louise
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2000
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86410/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11027270/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.21.8001-8007.2000
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