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Replication past O(6)-Methylguanine by Yeast and Human DNA Polymerase η

O(6)-Methylguanine (m6G) is formed by the action of alkylating agents such as N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) on DNA. m6G is a highly mutagenic and carcinogenic lesion, and it presents a block to synthesis by DNA polymerases. Here, we provide genetic and biochemical evidence for the invo...

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Detalhes bibliográficos
Main Authors: Haracska, Lajos, Prakash, Satya, Prakash, Louise
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86410/
https://ncbi.nlm.nih.gov/pubmed/11027270
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