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Replication past O(6)-Methylguanine by Yeast and Human DNA Polymerase η
O(6)-Methylguanine (m6G) is formed by the action of alkylating agents such as N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) on DNA. m6G is a highly mutagenic and carcinogenic lesion, and it presents a block to synthesis by DNA polymerases. Here, we provide genetic and biochemical evidence for the invo...
Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Microbiology
2000
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC86410/ https://ncbi.nlm.nih.gov/pubmed/11027270 |
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