Role of DNA Polymerase η in the Bypass of a (6-4) TT Photoproduct

UV light-induced DNA lesions block the normal replication machinery. Eukaryotic cells possess DNA polymerase η (Polη), which has the ability to replicate past a cis-syn thymine-thymine (TT) dimer efficiently and accurately, and mutations in human Polη result in the cancer-prone syndrome, the variant...

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Detalhes bibliográficos
Main Authors: Johnson, Robert E., Haracska, Lajos, Prakash, Satya, Prakash, Louise
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC100277/
https://ncbi.nlm.nih.gov/pubmed/11313481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3558-3563.2001
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