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Role of DNA Polymerase η in the Bypass of a (6-4) TT Photoproduct
UV light-induced DNA lesions block the normal replication machinery. Eukaryotic cells possess DNA polymerase η (Polη), which has the ability to replicate past a cis-syn thymine-thymine (TT) dimer efficiently and accurately, and mutations in human Polη result in the cancer-prone syndrome, the variant...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC100277/ https://ncbi.nlm.nih.gov/pubmed/11313481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3558-3563.2001 |
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