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Highly error-free role of DNA polymerase η in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells

Cyclobutane pyrimidine dimers (CPDs) constitute the most frequent UV-induced DNA photoproduct. However, it has remained unclear how human and other mammalian cells mitigate the mutagenic and carcinogenic potential of CPDs emanating from their replicative bypass. Here, we examine in human cells the r...

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Bibliografske podrobnosti
Main Authors: Yoon, Jung-Hoon, Prakash, Louise, Prakash, Satya
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775276/
https://ncbi.nlm.nih.gov/pubmed/19822754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910121106
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