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Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry

8-Oxo-7,8-dihydro-2′-deoxyguanosine (dOG), a well-studied oxidation product of 2′-deoxyguanosine (dG), is prone to facile further oxidation forming spiroiminodihydantoin 2′-deoxyribonucleoside (dSp) in the nucleotide pool and in single-stranded oligodeoxynucleotides (ODNs). Many methods for quantifi...

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Bibliografiske detaljer
Main Authors: Chen, Xin, Fleming, Aaron M., Muller, James G., Burrows, Cynthia J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929292/
https://ncbi.nlm.nih.gov/pubmed/24563606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3NJ00418J
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