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Characterization of 2′-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H(2)O(2)/reductant in nucleoside and oligodeoxynucleotide contexts(,)

Reactive oxygen species attack both base and sugar moieties in DNA with a preference among the bases for reaction at guanine. In the present study, 2′-deoxyguanosine (dG) was oxidized by a copper-mediated Fenton reaction with the reductants ascorbate or N-acetyl-cysteine, yielding oxidation on both...

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書誌詳細
主要な著者: Fleming, Aaron M., Muller, James G., Ji, Insun, Burrows, Cynthia J.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008943/
https://ncbi.nlm.nih.gov/pubmed/21445431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1ob05112a
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