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Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not hydroxyl radical

Product analysis from the iron Fenton oxidation of 2′-deoxyguanosine found reactions in bicarbonate buffer yield 8-oxo-2′-deoxyguanosine and spiroiminodihyantoin consistent with CO(3)(•−). Reactions in phosphate buffer furnished high yields of sugar oxidation products consistent with HO(•). These ob...

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Foilsithe in:Chem Commun (Camb)
Main Authors: Fleming, Aaron M., Burrows, Cynthia J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545335/
https://ncbi.nlm.nih.gov/pubmed/32716425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc04138f
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