Structural Context Effects in the Oxidation of 8-Oxo-7,8-dihydro-2’-deoxyguanosine to Hydantoin Products: Electrostatics, Base Stacking, and Base Pairing

8-Oxo-7,8-dihydroguanine (OG) is the most common base damage found in the cell where it resides in many structural contexts including the nucleotide pool, single-stranded DNA at transcription forks and replication bubbles, and in duplex DNA base paired with either A or C. OG is prone to further oxid...

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Bibliographic Details
Main Authors: Fleming, Aaron M., Muller, James G., Dlouhy, Adrienne C., Burrows, Cynthia J.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440533/
https://ncbi.nlm.nih.gov/pubmed/22880947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja306077b
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