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Sequencing DNA for the oxidatively modified base 8-oxo-7,8-dihydroguanine
The DNA base guanine (G) can be oxidatively modified to 8-oxo-7,8-dihydroguanine (OG). Extraction of genomic DNA followed by nuclease digestion and mass spectrometry analysis have found OG is present at background levels of ~1 out of 10(6) Gs; however, this approach cannot determine the locations fo...
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| Publicado no: | Methods Enzymol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5623582/ https://ncbi.nlm.nih.gov/pubmed/28645369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2017.03.004 |
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