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Human telomere G-quadruplexes with five repeats accommodate 8-oxo-7,8-dihydroguanine by looping out the DNA damage
Inflammation and oxidative stress generate free radicals that oxidize guanine (G) in DNA to 8-oxo-7,8-dihydroguanine (OG), and this reaction is prominent in the G-rich telomere sequence. In telomeres, OG is not efficiently removed by repair pathways allowing its concentration to build, surprisingly...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4828913/ https://ncbi.nlm.nih.gov/pubmed/26686913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00844 |
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