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Trinucleotide Repeat DNA Alters Structure to Minimize the Thermodynamic Impact of 8-Oxo-7,8-dihydroguanine()

In the phenomenon of trinucleotide repeat (TNR) expansion, an important interplay exists between DNA damage repair of 8-oxo-7,8-dihydroguanine (8-oxoG) and non-canonical structure formation. We show that TNR DNA adapts its structure to accommodate 8-oxoG. Using chemical probe analysis, we find that...

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Bibliografiska uppgifter
Huvudupphovsmän: Volle, Catherine B., Jarem, Daniel A., Delaney, Sarah
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254800/
https://ncbi.nlm.nih.gov/pubmed/22148399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201552s
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