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Trinucleotide Repeat DNA Alters Structure to Minimize the Thermodynamic Impact of 8-Oxo-7,8-dihydroguanine()
In the phenomenon of trinucleotide repeat (TNR) expansion, an important interplay exists between DNA damage repair of 8-oxo-7,8-dihydroguanine (8-oxoG) and non-canonical structure formation. We show that TNR DNA adapts its structure to accommodate 8-oxoG. Using chemical probe analysis, we find that...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3254800/ https://ncbi.nlm.nih.gov/pubmed/22148399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201552s |
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