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Sequence-specific Single-molecule Analysis of 8-Oxo-7,8-dihydroguanine Lesions in DNA based on Unzipping Kinetics of Complementary Probes in Ion Channel Recordings
Translocation measurements of intact DNA strands with the ion channel α-hemolysin (α-HL) are limited to single-stranded DNA (ssDNA) experiments as the dimensions of the channel prevent double-stranded DNA (dsDNA) translocation; however, if a short oligodeoxynucleotide is used to interrogate a longer...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173567/ https://ncbi.nlm.nih.gov/pubmed/21875081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205653v |
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