Sequence-specific Single-molecule Analysis of 8-Oxo-7,8-dihydroguanine Lesions in DNA based on Unzipping Kinetics of Complementary Probes in Ion Channel Recordings

Translocation measurements of intact DNA strands with the ion channel α-hemolysin (α-HL) are limited to single-stranded DNA (ssDNA) experiments as the dimensions of the channel prevent double-stranded DNA (dsDNA) translocation; however, if a short oligodeoxynucleotide is used to interrogate a longer...

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Hlavní autoři: Schibel, Anna E. P., Fleming, Aaron M., Jin, Qian, An, Na, Liu, Jin, Blakemore, Charles P., White, Henry S., Burrows, Cynthia J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173567/
https://ncbi.nlm.nih.gov/pubmed/21875081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205653v
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