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Characterization of 2′-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H(2)O(2)/reductant in nucleoside and oligodeoxynucleotide contexts(,)
Reactive oxygen species attack both base and sugar moieties in DNA with a preference among the bases for reaction at guanine. In the present study, 2′-deoxyguanosine (dG) was oxidized by a copper-mediated Fenton reaction with the reductants ascorbate or N-acetyl-cysteine, yielding oxidation on both...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4008943/ https://ncbi.nlm.nih.gov/pubmed/21445431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1ob05112a |
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