Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes

Eukaryotic DNA polymerase β (Pol β) plays an important role in cellular DNA repair, as it fills short gaps in dsDNA that result from removal of damaged bases. Since defects in DNA repair may lead to cancer and genetic instabilities, Pol β has been extensively studied, especially its mechanisms for s...

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Vydáno v:J Biol Chem
Hlavní autoři: Fijen, Carel, Mahmoud, Mariam M., Kronenberg, Meike, Kaup, Rebecca, Fontana, Mattia, Towle-Weicksel, Jamie B., Sweasy, Joann B., Hohlbein, Johannes
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335799/
https://ncbi.nlm.nih.gov/pubmed/32385112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013049
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