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Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes
Eukaryotic DNA polymerase β (Pol β) plays an important role in cellular DNA repair, as it fills short gaps in dsDNA that result from removal of damaged bases. Since defects in DNA repair may lead to cancer and genetic instabilities, Pol β has been extensively studied, especially its mechanisms for s...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335799/ https://ncbi.nlm.nih.gov/pubmed/32385112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013049 |
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