Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor: BINDING SITE ELUCIDATION AND RELATIONSHIP TO G PROTEIN SIGNALING

The cannabinoid 1 (CB(1)) allosteric modulator, 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide) (ORG27569), has the paradoxical effect of increasing the equilibrium binding of [(3)H](−)-3-[2-hydroxyl-4-(1,1-dimethylheptyl)phenyl]-4-[3-hydroxylpropyl]cyclohexan...

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Bibliografske podrobnosti
Main Authors: Shore, Derek M., Baillie, Gemma L., Hurst, Dow H., Navas, Frank, Seltzman, Herbert H., Marcu, Jahan P., Abood, Mary E., Ross, Ruth A., Reggio, Patricia H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937654/
https://ncbi.nlm.nih.gov/pubmed/24366865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.478495
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