Structural Basis of G Protein-coupled Receptor-G(i) Protein Interaction: FORMATION OF THE CANNABINOID CB(2) RECEPTOR-G(i) PROTEIN COMPLEX

In this study, we applied a comprehensive G protein-coupled receptor-Gα(i) protein chemical cross-linking strategy to map the cannabinoid receptor subtype 2 (CB(2))- Gα(i) interface and then used molecular dynamics simulations to explore the dynamics of complex formation. Three cross-link sites were...

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Detalhes bibliográficos
Main Authors: Mnpotra, Jagjeet S., Qiao, Zhuanhong, Cai, Jian, Lynch, Diane L., Grossfield, Alan, Leioatts, Nicholas, Hurst, Dow P., Pitman, Michael C., Song, Zhao-Hui, Reggio, Patricia H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106340/
https://ncbi.nlm.nih.gov/pubmed/24855641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.539916
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