Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones

A series of 1,3,4-oxadiazol-2-ones was synthesized and tested for activity as antagonists at GPR55 in cellular beta-arrestin redistribution assays. The synthesis was designed to be modular in nature so that a sufficient number of analogues could be rapidly accessed to explore initial structure-activ...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Autores principales: Meza-Aviña, Maria Elena, Lingerfelt, Mary A., Console-Bram, Linda M., Gamage, Thomas F., Sharir, Haleli, Gettys, Kristen E., Hurst, Dow P., Kotsikorou, Evangelia, Shore, Derek M., Caron, Marc G., Rao, Narasinga, Barak, Larry S., Abood, Mary E., Reggio, Patricia H., Croatt, Mitchell P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836065/
https://ncbi.nlm.nih.gov/pubmed/26916440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.02.030
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares