Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones

A series of 1,3,4-oxadiazol-2-ones was synthesized and tested for activity as antagonists at GPR55 in cellular beta-arrestin redistribution assays. The synthesis was designed to be modular in nature so that a sufficient number of analogues could be rapidly accessed to explore initial structure-activ...

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發表在:Bioorg Med Chem Lett
Main Authors: Meza-Aviña, Maria Elena, Lingerfelt, Mary A., Console-Bram, Linda M., Gamage, Thomas F., Sharir, Haleli, Gettys, Kristen E., Hurst, Dow P., Kotsikorou, Evangelia, Shore, Derek M., Caron, Marc G., Rao, Narasinga, Barak, Larry S., Abood, Mary E., Reggio, Patricia H., Croatt, Mitchell P.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836065/
https://ncbi.nlm.nih.gov/pubmed/26916440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.02.030
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