Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones

A series of 1,3,4-oxadiazol-2-ones was synthesized and tested for activity as antagonists at GPR55 in cellular beta-arrestin redistribution assays. The synthesis was designed to be modular in nature so that a sufficient number of analogues could be rapidly accessed to explore initial structure-activ...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Meza-Aviña, Maria Elena, Lingerfelt, Mary A., Console-Bram, Linda M., Gamage, Thomas F., Sharir, Haleli, Gettys, Kristen E., Hurst, Dow P., Kotsikorou, Evangelia, Shore, Derek M., Caron, Marc G., Rao, Narasinga, Barak, Larry S., Abood, Mary E., Reggio, Patricia H., Croatt, Mitchell P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836065/
https://ncbi.nlm.nih.gov/pubmed/26916440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.02.030
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