Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

BACKGROUND: There is increasing evidence of a constitutive activation of Akt in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance. Therefore, we evaluated the expression of phospho-Akt in PDAC tissues and cells, and investigated molecular mechanisms influenc...

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Vydáno v:J Hematol Oncol
Hlavní autoři: Massihnia, Daniela, Avan, Amir, Funel, Niccola, Maftouh, Mina, van Krieken, Anne, Granchi, Carlotta, Raktoe, Rajiv, Boggi, Ugo, Aicher, Babette, Minutolo, Filippo, Russo, Antonio, Leon, Leticia G., Peters, Godefridus J., Giovannetti, Elisa
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5219723/
https://ncbi.nlm.nih.gov/pubmed/28061880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0371-1
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