Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

BACKGROUND: Hypoxia is a driving force in pancreatic-ductal-adenocarcinoma (PDAC) growth, metastasis and chemoresistance. The muscle-isoform of lactate dehydrogenase (LDH-A) constitutes a major checkpoint for the switch to anaerobic glycolysis, ensuring supply of energy and anabolites in hypoxic-env...

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Detalhes bibliográficos
Main Authors: Maftouh, M, Avan, A, Sciarrillo, R, Granchi, C, Leon, L G, Rani, R, Funel, N, Smid, K, Honeywell, R, Boggi, U, Minutolo, F, Peters, G J, Giovannetti, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887288/
https://ncbi.nlm.nih.gov/pubmed/24178759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.681
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