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Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

Therapies that target the signal transduction and metabolic pathways of cancer stem cells (CSCs) are innovative strategies to effectively reduce the recurrence and significantly improve the outcome of glioblastoma multiforme (GBM). CSCs exhibit an increased rate of glycolysis, thus rendering them in...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Daniele, Simona, Giacomelli, Chiara, Zappelli, Elisa, Granchi, Carlotta, Trincavelli, Maria Letizia, Minutolo, Filippo, Martini, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616042/
https://ncbi.nlm.nih.gov/pubmed/26494310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15556
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