Salicylketoximes targeting glucose transporter 1 restrict energy supply to lung cancer cells

The glucose transporter GLUT1 is very frequently overexpressed in most tumor tissues because rapidly proliferating cancer cells rely mostly on glycolysis, a low-efficiency metabolic pathway necessitating a very high glucose consumption. Blocking GLUT1 is a promising anticancer strategy, thus we deve...

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Vydáno v:ChemMedChem
Hlavní autoři: Granchi, Carlotta, Qian, Yanrong, Lee, Hyang Yeon, Paterni, Ilaria, Pasero, Carolina, Iegre, Jessica, Carlson, Kathryn E., Tuccinardi, Tiziano, Chen, Xiaozhuo, Katzenellenbogen, John A., Hergenrother, Paul J., Minutolo, Filippo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743644/
https://ncbi.nlm.nih.gov/pubmed/26332543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500320
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