Salicylketoximes targeting glucose transporter 1 restrict energy supply to lung cancer cells

The glucose transporter GLUT1 is very frequently overexpressed in most tumor tissues because rapidly proliferating cancer cells rely mostly on glycolysis, a low-efficiency metabolic pathway necessitating a very high glucose consumption. Blocking GLUT1 is a promising anticancer strategy, thus we deve...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:ChemMedChem
Main Authors: Granchi, Carlotta, Qian, Yanrong, Lee, Hyang Yeon, Paterni, Ilaria, Pasero, Carolina, Iegre, Jessica, Carlson, Kathryn E., Tuccinardi, Tiziano, Chen, Xiaozhuo, Katzenellenbogen, John A., Hergenrother, Paul J., Minutolo, Filippo
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743644/
https://ncbi.nlm.nih.gov/pubmed/26332543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500320
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares