Synthesis and Biological Evaluation in U87MG Glioma Cells of (Ethynylthiophene)Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors

Matrix metalloproteinases (MMPs) are important factors in gliomas since these enzymes facilitate invasion into the surrounding brain and participate in neovascularization. In particular, the gelatinases (MMP-2 and MMP-9), and more recently MMP-25, have been shown to be highly expressed in gliomas an...

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Hauptverfasser: Nuti, Elisa, Casalini, Francesca, Santamaria, Salvatore, Gabelloni, Pamela, Bendinelli, Sara, Da Pozzo, Eleonora, Costa, Barbara, Marinelli, Luciana, La Pietra, Valeria, Novellino, Ettore, Bernardo, M. Margarida, Fridman, Rafael, Da Settimo, Federico, Martini, Claudia, Rossello, Armando
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319704/
https://ncbi.nlm.nih.gov/pubmed/21514700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.03.033
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